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작성일 : 12-04-27 11:15
5/3(목) 화학과 세미나 공지
 글쓴이 : 응용화학과
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* 일시 : 201253일 목요일 오후 430
* 장소 : 공학관 107
* 연사 : 손영숙 교수 [경희대학교 유전공학과]
* 주제 : Stem Cell Mobilization for Tissue Repair
* 초록 :
Stem Cell Mobilization for Tissue Repair
Hyun Sook Hong1, Jungsun Lee2, EunAh Lee1, Woosung Ahn1, Jae Chan Kim3, Youngsook Son1, 1Department of Genetic Engineering, Kyung Hee University, Korea, 2R&D Institute McTT, 3Dept of Ophthalmology, Chung Ang University. ysson@khu.ac.kr
Tissue injury may create a specific microenvironment, which brings up the systemic participation of reparative stem cells in the repair process. Previously, we identified a new role of substance-P (SP) as an injury-inducible messenger to mobilize bone marrow stromal cells, namely mesenchymal stem cells (BMSC or MSC) from the marrow to the blood, home to the injured tissue, and be engaged in the tissue repair in the alkali-burn corneal injury model (Nature Medicine, 2009 April). This elucidates endogenous healing mechanism recalling BMSC to the wound site. In addition to SP’s BMSC mobilizer function, SP also mobilize endothelial precursor cells (EPC) from the bone marrow to the peripheral blood. When NK-1 receptor positive cells were isolated from the blood by MACS analysis after the SP injection, CD34+ Urex+ adherent cells were detected and also confirmed to be EPC by marker ____EXPRESSION____s, Matrigel endothelial tube formation, and in vivo vasculogenesis in the wound model. SP’s EPC mobilization pattern was rather distinct from that of G-CSF previously reported. In contrast to the strong inflammatory response of G-CSF, its major unwanted effect for the use of tissue injury, SP did not accompany inflammatory response in the injury model but rather suppressed the injury-stimulated inflammation response. This inflammation-suppressive role of SP came earlier than its BMSC and EPC mobilization effect, which seems to be directly mediated by blood cells through the action of M2 type macrophage transformation and regulatory T cells induction. We explored SP’s dual positive roles in the orchestration of the tissue repair in a variety of the animal models such as the spinal cord injury, radiation-induced BM injury, and gastrointestinal injury. At the early stage of wound healing, anti-inflammatory effect of SP seems to play positive roles in the reduction of inflammation-induced secondary cell death, in the creation of favorable microenvironment for the engraftment of incoming stem cells, later, and finally in the facilitation of tissue repair. Acknowledgements: This work was supported by Stem Cell Research Center of 21 C Frontier Project (2004-2012) and Excellence Team of Stem Cell Research(2010-2015) from Ministry of Education and Science and Technology (MEST) given to Dr YSon.
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